as soon as possible
full-time; initially limited for 3 years according to WissZeitVG
Your salary will be based on TV-L

» Your tasks

We are looking for a passionate postdoctoral fellow to explore the role of nucleic acid sensing in Small Cell Lung Cancer (SCLC) progression, immune interactions and therapy response. This opportunity involves unraveling innate immune pathways and their activation to potentially instigate immunogenicity and induce cell death in these tumors. You will leverage cutting-edge in vivo and in vitro cancer models, alongside genomics, proteomics, and transcriptomics techniques.

Your responsibilities will include:

  • Generation of CRISPR-Cas9 edited cells and mice
  • Analysis of intra- and intercellular signaling pathways
  • Investigating tumor-infiltrating immune cells in vivo
  • Overseeing a vital mouse colony
  • Collaboration across various scientific disciplines
  • Literature research and data analysis

» Your Profile

Are you a dynamic, driven scientist aspiring to make significant contributions to cancer treatment through translational research? If so, this postdoctoral position is for you. To be eligible, you should have a PhD or equivalent in a relevant field. We value prior experience with mouse models and in vivo cancer research. Ideal candidates will demonstrate:

  • A strong foundation in cancer cell biology, immunology, biochemistry, or related fields.
  • A proven research track record in research, as evidenced by publications.
  • In-depth knowledge of immunology, including expertise in immune cell types and subtypes analysis.
  • A self-motivated approach to independently drive research projects.
  • An enthusiastic, resilient, and positive mindset.
  • A collaborative spirit, complemented by excellent English communication skills.

 

Have we awakened your interest? Please submit your application (including a detailed CV, list of publications, two references and a brief statement of research interests) here online.

» Our Offer

Join our vibrant team at the interface of the Department of Translational Genomics, the Mildred Scheel School of Oncology, and the Centre for Molecular Medicine Cologne (CMMC). This position offers invaluable mentoring opportunities and interactions with global scientific leaders. You'll benefit from our collaborative environment in Cologne, with access to state-of-the-art facilities for genomics, proteomics, imaging, and a direct link to clinical applications.

» Your future with us

Working at the University Hospital Cologne and the Medical Faculty means helping to shape the future - the future of medicine, of patients and, of course, your own future. You benefit from 60 clinics and institutes as well as numerous other departments and facilities and more than 12,000 jobs. The Faculty of Medicine of the University of Cologne and the University Hospital Cologne assume important social tasks in research, teaching and patient care. A close network with many university and non-university partners guarantees an internationally successful science and the excellent education of our students.

» Your future in detail

The Brägelmann Lab, based within the Department of Translational Genomics under Prof. Roman Thomas, is committed to improving patient care by studying the evolution of tumors and their microenvironment. We concentrate on how cancers adapt to specific mutations or treatments, aiming to craft personalized therapeutic strategies (Brägelmann et al., Clin Can Res 2017; Brägelmann et al., Cell Rep 2017; Müller, … Brägelmann, Can Res 2023). In Non-Small Cell Lung Cancer, nucleic acid receptor agonists enhance therapy response via immunological rewiring and cancer cell death (Brägelmann et al., Nature Comm 2021). We are now extending this promising approach to Small Cell Lung Cancer (SCLC), focusing on the potential of nucleic acid receptors to improve therapy response and immunogenicity.

As a part of our team in the DFG-funded collaborative research center (Sonderforschungsbereich) 1399, the postdoctoral fellow we seek will play a pivotal role in this groundbreaking research. You will have the opportunity to work under the guidance of Dr. Johannes Brägelmann, focusing on cancer immunology, inflammation, and cancer genomics. The project will involve intensive investigation into nucleic acid sensing pathways in SCLC, utilizing advanced tools and methodologies such as CRISPR-editing for in vitro and in vivo models, transcriptomics, and advanced imaging techniques.

Interested to get in touch? Submit your online application (CV, publication list, two references and a brief statement of research interests) here.


People with disabilities are welcome to apply and will be treated preferentially in the event of equal suitability and qualification.

The position is suitable for staffing with part-time employees.

Dr. Johannes Brägelmann
+49 221 478-98777
https://www.uk-koeln.de
Application deadline: 10.03.2024
Universitätsklinikum Köln AöR
PA16
Geschäftsbereich Personal
Job-ID: 00004384
50937 Köln